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KMID : 0379520130290030217
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한국독성학회지
2013 Volume.29 No. 3 p.217 ~ p.219
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Mutagenic Assessment of Olmesartan Cilexetil by Bacterial Mutation Assay
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Kim Ji-Won
Ahn Il-Young
Ryu Sung-Ha
Jeon Hong-Ryeol
Lee Bong-Sang
Kim Kyu-Bong
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Abstract
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Hypertension is a serious health problem due to high frequency and concomitant other diseases including cardiovascular and renal dysfunction. Olmesartan cilexetil is a new antihypertensive drug associated with angiotensin II receptor antagonist. This study was conducted to evaluate the mutagenicity of olmesartan cilexetil by bacterial reverse mutation test using Salmonella typhimurium (TA100, TA1535, TA98, and TA1537) and Escherichia coli (WP2 uvrA). At the concentrations of 0, 62, 185, 556, 1667, and 5000 μg/ plate, olmesartan cilexetil was negative in both Salmonella typhimurium and Escherichia coli regardless of presence or absence of metabolic activation system (S9 mix). These results demonstrate that olmesartan cilexetil does not induce bacterial reverse mutation.
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KEYWORD
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Hypertension, Olmesartan cilexetil, Angiotension II receptor antagonist, Mutagenicity
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